The Role of Lutein, Zeaxanthin, and Fish Oil On Cognitive Function and Bone Health in Young Adults
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abstract
Lutein, zeaxanthin, and fish oil have been demonstrated to affect age-related macular degeneration, cognitive decline, and osteoporosis, which typically develop in later life when mitigation impacts tend to be severely blunted. This study aims to develop a precision nutrition model for preventing and attenuating age-related macular degeneration, cognition, and bone health in young adults. Healthy individuals ages 18-35 with a high-risk macular pigment optical density (MPOD) <.38 will participate in a 6-month randomized control trial to evaluate the impact of lutein, zeaxanthin, and fish oil on cognitive performance, MPOD, and bone health. The central hypothesis is that individuals with MPOD <.38 who take the supplements with 7 mg lutein, 14 mg zeaxanthin, and 245 mg fish oil will have a significant improvement in MPOD levels, cognitive performance, and bone density compared to placebo control after 6- months.  The model for precision nutrition includes non-invasive screening for high-risk carotenoid deficiencies (MPOD, dietary intake) and examining variability in responsiveness to a chronic intervention to develop precise individual dietary prescriptions.
