Social stress alters the severity of an animal model of multiple sclerosis
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Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) and a leading cause of disability among young adults (Anderson et al., 1992; Jacobson et al., 1997; Noonan et al., 2002; Sorpedra and Martin, 2005). Common symptoms include loss of motor control or sensation in the limbs, loss of bowel or bladder control, neuropathic pain, optic neuritis, sexual dysfunction, and cognitive dysfunction. The etiology of MS remains uncertain; however, considerable evidence suggests that environmental factors interact with genetic factors to cause disease (Kurtzke and Hyllested, 1987; Noseworthy et al., 2000; Sospedra and Martin, 2005). Suspected environmental factors include viral infection and stress. 2006 Springer Science+Business Media, LLC.