Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release.

abstract

• Chronic social disruption stress (SDR) exacerbates acute and chronic phase Theiler's murine encephalomyelitis virus (TMEV) infection, a mouse model of multiple sclerosis. However, the precise mechanism by which this occurs remains unknown. The present study suggests that SDR exacerbates TMEV disease course by priming virus-induced neuroinflammation. It was demonstrated that IL-1 mRNA expression increases following acute SDR; however, IL-6 mRNA expression, but not IL-1, is upregulated in response to chronic SDR. Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1 mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation.

authors

• Meagher, Mary
• Welsh, Christabel Jane

published proceedings

• J Neuroimmunol

altmetric score

• 1

author list (cited authors)

• Vichaya, E. G., Young, E. E., Frazier, M. A., Cook, J. L., Welsh, C. J., & Meagher, M. W.

citation count

• 10

complete list of authors

• Vichaya, EG||Young, EE||Frazier, MA||Cook, JL||Welsh, CJ||Meagher, MW

publication date

• January 2011

publisher

• Elsevier  Publisher

published in

• JOURNAL OF NEUROIMMUNOLOGY  Journal

keywords

• Animals
• Chronic Disease
• Disease Models, Animal
• Encephalitis, Viral
• Gene Expression Regulation, Viral
• Interleukin-1beta
• Interleukin-6
• Male
• Mice
• Mice, Inbred BALB C
• Multiple Sclerosis
• Random Allocation
• Social Environment
• Stress, Psychological
• Theilovirus
• Up-Regulation

PubMed Central ID

• 22000153

Digital Object Identifier (DOI)

• 10.1016/j.jneuroim.2011.08.006

start page

• 44

end page

• 52

volume

• 239

issue

• 1-2

URL

• http://dx.doi.org/10.1016/j.jneuroim.2011.08.006