Social stress alters the severity of acute Theiler's virus infection. Academic Article

abstract

• Our laboratory has previously shown that restraint stress resulted in decreased Theiler's virus-induced CNS inflammation, while exacerbating illness behaviors during the acute phase of disease. In contrast, social disruption stress (SDR) applied prior to infection led to the development of glucocorticoid (GC) resistance, and these animals developed more severe disease course, with increased inflammation. However, when SDR was applied concurrent with infection, GC resistance fails to develop, disease course is less severe and inflammation was moderate. These results suggest that the effects of SDR on Theiler's virus infection are dependent upon the timing of SDR application in relation to infection.

authors

• Meagher, Mary
• Welsh, Christabel Jane
• Welsh, Thomas

published proceedings

• J Neuroimmunol

author list (cited authors)

• Johnson, R. R., Storts, R., Welsh, T. H., Welsh, C., & Meagher, M. W.

citation count

• 45

complete list of authors

• Johnson, RR||Storts, R||Welsh, TH||Welsh, CJR||Meagher, MW

publication date

• January 2004

publisher

• Elsevier  Publisher

published in

• JOURNAL OF NEUROIMMUNOLOGY  Journal

keywords

• Acute Disease
• Analysis Of Variance
• Animals
• Behavior, Animal
• Cardiovirus Infections
• Corticosterone
• Gliosis
• Male
• Meningitis
• Mice
• Mice, Inbred BALB C
• Random Allocation
• Spinal Cord
• Stress, Physiological
• Theilovirus
• Time Factors

Digital Object Identifier (DOI)

• 10.1016/j.jneuroim.2003.11.009

start page

• 74

end page

• 85

volume

• 148

issue

• 1-2

URL

• http://dx.doi.org/10.1016/j.jneuroim.2003.11.009