Social disruption alters pain and cognition in an animal model of multiple sclerosis. Academic Article

abstract

• Although pain and cognitive deficits are widespread and debilitating symptoms of multiple sclerosis (MS), they remain poorly understood. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS where disease course is exacerbated by prior stressors. Here chronic infection coupled with prior social stress increased pain behavior and impaired hippocampal-dependent memory consolidation during the demyelinating phase of disease in SJL mice. These results suggest that the TMEV model may be useful in investigating pain and cognitive impairments in MS. However, in contrast to prior Balb/cJ studies, stress failed to consistently alter behavioral and physiological indicators of disease course.

authors

• Meagher, Mary
• Welsh, Christabel Jane

published proceedings

• J Neuroimmunol

altmetric score

• 0.25

author list (cited authors)

• Linsenbardt, H. R., Cook, J. L., Young, E. E., Vichaya, E. G., Young, C. R., Reusser, N. M., ... Meagher, M. W.

citation count

• 4

complete list of authors

• Linsenbardt, HR||Cook, JL||Young, EE||Vichaya, EG||Young, CR||Reusser, NM||Storts, R||Welsh, CJ||Meagher, MW

publication date

• January 2015

publisher

• Elsevier  Publisher

published in

• JOURNAL OF NEUROIMMUNOLOGY  Journal

keywords

• Animals
• Behavior, Animal
• Cardiovirus Infections
• Cognition
• Disease Models, Animal
• Male
• Mice
• Multiple Sclerosis
• Pain
• Pavlovian Conditioning
• Social Stress
• Stress, Psychological
• Theiler's Murine Encephalomyelitis Virus
• Theilovirus

PubMed Central ID

• 26531695

Digital Object Identifier (DOI)

• 10.1016/j.jneuroim.2015.09.005

start page

• 56

end page

• 68

volume

• 288

URL

• http://dx.doi.org/10.1016/j.jneuroim.2015.09.005