Mammalian evolution and biomedicine: new views from phylogeny. Academic Article

abstract

• Recent progress resolving the phylogenetic relationships of the major lineages of mammals has had a broad impact in evolutionary biology, comparative genomics and the biomedical sciences. Novel insights into the timing and historical biogeography of early mammalian diversification have resulted from a new molecular tree for placental mammals coupled with dating approaches that relax the assumption of the molecular clock. We highlight the numerous applications to come from a well-resolved phylogeny and genomic prospecting in multiple lineages of mammals, from identifying regulatory elements in mammalian genomes to assessing the functional consequences of mutations in human disease loci and those driving adaptive evolution.

authors

• Murphy, William

published proceedings

• Biol Rev Camb Philos Soc

author list (cited authors)

• Springer, M. S., & Murphy, W. J.

citation count

• 87

complete list of authors

• Springer, Mark S||Murphy, William J

publication date

• August 2007

publisher

• Wiley  Publisher

published in

• Biological Reviews  Journal

keywords

• Animals
• Biological Evolution
• Evolution, Molecular
• Female
• Genetic Variation
• Genomics
• Male
• Mammals
• Mutation
• Mutation, Missense
• Phylogeny

Digital Object Identifier (DOI)

• 10.1111/j.1469-185X.2007.00016.x

start page

• 375

end page

• 392

volume

• 82

issue

• 3

URL

• http://dx.doi.org/10.1111/j.1469-185x.2007.00016.x