DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP). Academic Article uri icon


  • The HELP assay is a technique that allows genome-wide analysis of cytosine methylation. Here we describe the assay, its relative strengths and weaknesses, and the transition of the assay from a microarray to massively-parallel sequencing-based foundation.

published proceedings

  • Methods

author list (cited authors)

  • Suzuki, M., & Greally, J. M.

citation count

  • 25

publication date

  • November 2010