The Effects of Resistance Training with L-carnitine Supplementation on Total Antioxidant Capacity and Lipid Peroxidation in Untrained Men
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Background & PurposeExercise training can disrupt the balance between free radical production and the body antioxidant defense system resulting in a condition known as oxidative stress. The purpose of the present study was to examine the effects of eight weeks of resistance training with Lcarnitine supplementation on total antioxidant capacity (TAC) and malondialdehyde (MDA) in untrained males.MethodologyIn a doublemasked, randomized, placebocontrolled study, 20 untrained males (age= 251yrs) were assigned into either supplement (n=9) or placebo (n=11) groups. Both groups followed the same resistance training program three days per week for eight consecutive weeks. During the study, the supplement group received Lcarnitine 2g daily, and the placebo group received maltodextrin capsules. Anthropometric measurements, dietary intakes and blood markers including TAC and MDA were measured pre and post treatment data were analyzed using paired t test, independent ttest and analysis of covariance at the significance level of P0.05. Statistical analysis was performed using the SPSS version 22.0 software.ResultsResults showed that the supplement group experienced a significant increase in TAC as well as a significant decrease in serum MDA levels following the training program (P0.05), while there was only a significant difference at serum MDA levels between groups following the training (P0.05). Furthermore, no significant difference was found in variables in the placebo group following the training program (P>0.05).ConclusionPresent findings suggest that 2 g/day of Lcarnitine increases the activity of antioxidant enzymes and the TAC in healthy subjects. Lcarnitine supplementation might be a considered as a protective strategy to regulate oxidative stress during exercise training period.
