Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21. Academic Article

abstract

• Five genes on human chromosome 7 (HSA 7) were assigned to bovine chromosome 21 (BTA 21) and 4 (BTA 4) using a bovine-rodent somatic hybrid cell panel. These five genes were alpha-I subunit of adenylate cyclase-inhibiting G-protein (GNAI1), alpha/beta preprotachykinin (TAC1), reelin (RELN), c-AMP dependant protein kinase type II beta regulatory chain (PRKAR2B) and apolipoprotein A1 regulatory protein 1 (TFCOUP2). Four genes mapped to BTA 4 (GNAI1, TAC1, RELN, PRKAR2B) while one gene mapped to BTA 21 (TFCOUP2). This study confirms the synteny conservation between HSA 7 and BTA 4, finely maps the breakpoints of conserved synteny on HSA 7 and defines a new synteny conservation between HSA 7 and BTA 21.

authors

• Womack, James

published proceedings

• Cytogenet Cell Genet

author list (cited authors)

• Antoniou, E., Womack, J. E., & Grosz, M. D.

citation count

• 1

complete list of authors

• Antoniou, E||Womack, JE||Grosz, MD

publication date

• May 1999

publisher

• Karger Publishers  Publisher

published in

• Cytogenetic and Genome Research  Journal

keywords

• Adenylyl Cyclase Inhibitors
• Animals
• Base Sequence
• COUP Transcription Factors
• Cattle
• Cell Adhesion Molecules, Neuronal
• Chromosome Mapping
• Chromosomes, Human, Pair 7
• Cyclic AMP-Dependent Protein Kinases
• Cyclic Amp-dependent Protein Kinase Riibeta Subunit
• Cyclic Amp-dependent Protein Kinase Type Ii
• DNA Primers
• DNA-Binding Proteins
• Extracellular Matrix Proteins
• GTP-Binding Proteins
• Humans
• Hybrid Cells
• Nerve Tissue Proteins
• Polymerase Chain Reaction
• Protein Precursors
• Receptors, Steroid
• Reelin Protein
• Serine Endopeptidases
• Species Specificity
• Tachykinins
• Transcription Factors

PubMed Central ID

• 10343125

Digital Object Identifier (DOI)

• 10.1159/000015236

start page

• 121

end page

• 124

volume

• 84

issue

• 1-2

URL

• http://dx.doi.org/10.1159/000015236