Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme. Academic Article uri icon

abstract

  • Genetic variation among inbred strains is described for electrophoretic migration of alkaline phosphatase from intestine, kidney, blood plasma, and three isozymes of liver. A manganese-requiring isozyme of liver and kidney unaffected by neuraminidase is described, and the locus controlling variation in this isozyme is designated Akp-1. Data from recombinant inbred strains place the locus on chromosome 1 at a distance of 3.6 +/- 2.9 cM from the M1s locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1.

published proceedings

  • Biochem Genet

author list (cited authors)

  • Wilcox, F. H., Hirschhorn, L., Taylor, B. A., Womack, J. E., & Roderick, T. H.

citation count

  • 38

complete list of authors

  • Wilcox, FH||Hirschhorn, L||Taylor, BA||Womack, JE||Roderick, TH

publication date

  • December 1979