Syntenic assignments of visual transduction genes in cattle. Academic Article

abstract

• To establish syntenic relationships of phototransduction genes, we have mapped the genes encoding the alpha-, beta-, and gamma-subunits of rod cGMP phosphodiesterase (PDE) (PDEA, PDEB, PDEG), the alpha'-subunit of cone PDE (PDEA2), and the rod cGMP-gated channel (CNCG) to bovine syntenic groups. The rod cGMP PDE alpha-, beta-, and gamma-subunit genes map to bovine syntenic groups U22, U15 (chromosome 6), and U21 (chromosome 19), respectively. The rod cGMP-gated channel gene also maps to syntenic group U15, and the bovine cone alpha'-subunit gene maps to U26 (chromosome 26). With the exception of the cone PDE alpha'-subunit gene, which has not been mapped in other mammals, all of these genes have been assigned to conserved chromosomal regions shared among bovine, human, and mouse. A compilation of currently known syntenic assignments and predictions regarding future assignments of phototransduction genes in human, mouse, and cattle is presented.

authors

• Womack, James

published proceedings

• Genomics

author list (cited authors)

• Gallagher, D. S., Womack, J. E., Baehr, W., & Pittler, S. J.

citation count

• 4

complete list of authors

• Gallagher, DS||Womack, JE||Baehr, W||Pittler, SJ

publication date

• November 1992

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• 3',5'-Cyclic-GMP Phosphodiesterases
• Animals
• Base Sequence
• Blotting, Southern
• Cattle
• Chromosome Mapping
• Cyclic Nucleotide-gated Cation Channels
• DNA, Single-Stranded
• Eye Proteins
• Humans
• Ion Channels
• Molecular Sequence Data
• Photic Stimulation
• Photoreceptor Cells
• Signal Transduction
• Vision, Ocular

PubMed Central ID

• 1330890

Digital Object Identifier (DOI)

• 10.1016/s0888-7543(05)80171-5

start page

• 699

end page

• 706

volume

• 14

issue

• 3

URL

• http://dx.doi.org/10.1016/s0888-7543(05)80171-5