Peptidase-3 (Pep-3), dipeptidase variant in the rat homologous to mouse pep-3 (Dip-1) and human PEP-c. Academic Article

abstract

• Starch gel electrophoresis and histochemical staining with L-leucyl-L-tyrosine have revealed genetic variation for dipeptidase in Rattus norvegicus. The tissue distribution, substrate specificity, and heterozygous expression as a monmeric protein suggest homology of the variant peptidase to human PEP-C and mouse Pep-3 (Dip-1). We propose Peptidase-3 (Pep-3) as a name for this autosomal locus in the rat. The allele responsible for slower (less anodal) electrophoretic migration is designated Pep-3a and is characteristic of strain ACI/Pit. A faster (more anodal) electrophoretic mobility is the product of the Pep-3b allele in strain F344/Pit. Twenty-five additional inbred strains carry Pep-3a and 16 others carry Pep-3b. Wild rats trapped in Pittsburgh were polymorphic for this locus. Alleles at Pep-3 segregated independently of c (linkage group I), a (linkage group IV), RT2 and Es-1 (linkage group V), h (linkage group VI), and RTI (linkage group VIII).

authors

• Womack, James

published proceedings

• Biochem Genet

author list (cited authors)

• Womack, J. E., & Cramer, D. V.

citation count

• 29

complete list of authors

• Womack, JE||Cramer, DV

publication date

• October 1980

publisher

• Springer Nature  Publisher

keywords

• Animal Population Groups
• Animals
• Animals, Wild
• Dipeptidases
• Electrophoresis, Starch Gel
• Erythrocytes
• Female
• Genes
• Genetic Variation
• Male
• Rats
• Rats, Inbred Strains

Digital Object Identifier (DOI)

• 10.1007/BF00500132

start page

• 1019

end page

• 1026

volume

• 18

issue

• 9-10

URL

• http://dx.doi.org/10.1007/bf00500132