Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases. Academic Article

abstract

• The low activity of liver neuraminidase that is characteristic of mouse strain SM/J is inherited as a single gene on chromosome 17, near the major histocompatibility complex. This gene, neuraminidase-1 (Neu-1), is represented by the low activity allele Neu-1s in SM/J and the high activity allele Neu-1b in C57BL/6J and most other strains. Previously described variations in the posttranslational processing of acid phosphatase, alpha-mannosidase, arylsulfatase-B, and alpha-glucosidase are attributed to pleiotropic effects of this gene.

authors

• Womack, James

published proceedings

• Science

author list (cited authors)

• Womack, J. E., Yan, D. L., & Potier, M.

citation count

• 63

complete list of authors

• Womack, JE||Yan, DL||Potier, M

publication date

• April 1981

publisher

• American Association for the Advancement of Science (AAAS)  Publisher

published in

• Science  Journal

keywords

• Alleles
• Animals
• Chromosome Mapping
• Female
• H-2 Antigens
• Hydrolases
• Liver
• Major Histocompatibility Complex
• Male
• Mice
• Mice, Inbred Strains
• Neuraminidase
• Protein Precursors
• Recombination, Genetic
• Sialic Acids

PubMed Central ID

• 7209520

Digital Object Identifier (DOI)

• 10.1126/science.7209520

start page

• 63

end page

• 65

volume

• 212

issue

• 4490

URL

• http://dx.doi.org/10.1126/science.7209520