Orotic acid excretion in some wild-type strains of Escherichia coli K-12.
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During rapid growth, the excretion of pyrimidines, predominantly uracil, is a common phenomenon in procaryotes and eucaryotes. In Escherichia coli, some K-12 strains excrete orotic acid and not uracil. This is caused by a mutation in the pyrF gene.
author list (cited authors)
Womack, J. E., & O'Donovan, G. A.