Mapping HSA10 homologous loci in cattle. Conference Paper

abstract

• Loci homologous to those on human chromosome 10 (HSA10) map to five mouse chromosomes, MMU2, MMU7, MMU10, MMU14, and MMU19. In cattle, one unassigned syntenic group (U26) was previously defined by the HSA10/MMU19 isoenzyme marker glutamic-oxaloacetic transaminase 1 (GOT1). To evaluate the syntenic arrangement of other HSA10 loci in cattle, seven genes were physically mapped by segregation analysis in a bovine x hamster hybrid somatic cell panel. The genes mapped include: vimentin (VIM) on HSA10 and MMU2; interleukin 2 receptor (IL2R) on HSA10 and MMU?; ornithine aminotransferase (OAT) on HSA10 and MMU7; hexokinase 1 (HK1) on HSA10 and MMU10; retinol-binding protein 3 (RBP3) on HSA10 and MMU14; plasminogen activator, urokinase type (PLAU) on HSA10 and MMU14; and alpha-2-adrenergic receptor (ADRA2) on HSA10 and MMU19. VIM and IL2R mapped to U11; ADRA2 and OAT mapped to U26; and RBP3, PLAU, and HK1 mapped to U28.

authors

• Threadgill, Deborah

published proceedings

• Cytogenet Cell Genet

author list (cited authors)

• Threadgill, D. S., & Womack, J. E.

citation count

• 11

complete list of authors

• Threadgill, DS||Womack, JE

publication date

• January 1991

publisher

• Karger Publishers  Publisher

published in

• Cytogenetic and Genome Research  Journal

keywords

• Animals
• Cattle
• Chromosome Banding
• Chromosome Mapping
• Chromosomes, Human, Pair 10
• Cricetinae
• Hexokinase
• Humans
• Hybrid Cells
• Isoenzymes
• Mice
• Ornithine-Oxo-Acid Transaminase
• Receptors, Adrenergic, Alpha
• Receptors, Interleukin-2
• Retinol-binding Proteins
• Urokinase-Type Plasminogen Activator
• Vimentin

PubMed Central ID

• 1655359

Digital Object Identifier (DOI)

• 10.1159/000133130

start page

• 123

end page

• 126

volume

• 57

issue

• 2-3

URL

• http://dx.doi.org/10.1159/000133130