Characterization of HCO3-/CO2 pool sizes and kinetics in infants.
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The first bicarbonate pool sizes and kinetic data necessary for the interpretation of substrate oxidation studies have been determined in six fed, nonacidotic infants, ages 2.5 to 5 months. Following an intravenous bolus of NaH13CO3 (50 mumol/kg), breath samples were collected over 240 min for the analysis of breath 13CO2. Each breath 13CO2 disappearance curve was fitted to a multicompartmental bicarbonate model previously derived in adults. The mean sizes of the three bicarbonate pools were: 7.4 +/- 0.8 mmol/kg (central pool), 15.1 +/- 4.8 mmol/kg (rapidly exchanging peripheral pool), and 8.8 +/- 3.5 mmol/kg (slowly exchanging peripheral pool). The mean percentage dose recovery was 57 +/- 10%. The pool sizes suggested that extensive metabolic exchange of carbon between HCO3- and organic metabolites occurred in the infant.
author list (cited authors)
Irving, C. S., Lifschitz, C. H., Wong, W. W., Boutton, T. W., Nichols, B. L., & Klein, P. D.
complete list of authors
Irving, CS||Lifschitz, CH||Wong, WW||Boutton, TW||Nichols, BL||Klein, PD