A radiation hybrid map of bovine X chromosome (BTAX). Academic Article uri icon


  • We present a comprehensive radiation hybrid map of the bovine X chromosome (Chr) containing 20 new markers, including both microsatellites and expressed genes. This study was conducted with a 5000-rad whole genome RH cell panel consisting of 90 hybrid cell lines. Retention frequencies of individual markers range from 7.8% for XIST to 31.1% for TGLA325. Statistical analysis with RHMAPPER placed all the loci into five linkage groups under a LOD score criterion of 6.0. These groups could be oriented relative to each other because they included multiple microsatellite loci from the consensus linkage map of the X Chr. Markers included in both this RH map and the bovine cytogenetic map were in a consistent order. The comparative bovine-human map thus generated consists of five blocks of genes, the order of which is conserved, although in the opposite direction when presented as ideograms with p and q arms. Inversions of three blocks account for the difference in gene order across the entirety of the two X Chrs.

published proceedings

  • Mamm Genome

author list (cited authors)

  • Amaral, M., Kata, S. R., & Womack, J. E.

citation count

  • 21

complete list of authors

  • Amaral, M Elisabete J||Kata, Srinivas R||Womack, James E

publication date

  • May 2002