Identification of an autosome to X chromosome translocation in the domestic cow. Academic Article uri icon

abstract

  • Chromosomes were harvested from two fibroblast lines derived from a phenotypically normal cow and her albino daughter, both known to be heterozygous for an X/autosome translocation. QFH-banding after early BrdU incorporation identified the translocated autosomal material as chromosome 23 bands 13-25, and revealed that the centromeric portion of the translocated chromosome 23 had been retained. Fluorescent in situ hybridization of a BoLA Class I cDNA probe to the normal chromosome 23 and to the translocated autosomal material confirmed the identity of the translocation, and allowed a more precise sublocalization of the MHC in cattle than that previously reported.

published proceedings

  • J Hered

author list (cited authors)

  • Gallagher, D. S., Basrur, P. K., & Womack, J. E.

citation count

  • 20

complete list of authors

  • Gallagher, DS||Basrur, PK||Womack, JE

publication date

  • December 1992