A radiation hybrid map of bovine chromosome one Academic Article uri icon

abstract

  • Radiation hybrid (RH) mapping has proven to be an extremely powerful approach to constructing high density maps of human chromosomes and is experiencing increased use in other animals, including cattle. A 5000 rad bovine whole-genome radiation hybrid panel was recently constructed in order to integrate existing cattle linkage maps with evolutionarily conserved genes and provide high resolution comparative maps relative to humans and mice. We utilized this panel to construct a 19 marker framework map of bovine chromosome 1 (BTA1), which included 8 Type I loci and 11 Type II loci ordered with at least 1000:1 odds. A 35 marker comprehensive map including 15 Type I loci and 20 Type II loci was also produced. Of the 15 Type I loci ordered on the comprehensive map, three are ordered on HSA3 and five are ordered in three blocks on HSA21 on the human cytogenetic maps.

author list (cited authors)

  • Rexroad, C. E., Schlapfer, J. S., Yang, Y., Harlizius, B., & Womack, J. E.

citation count

  • 18

complete list of authors

  • Rexroad, CE||Schlapfer, JS||Yang, Y||Harlizius, B||Womack, JE

publication date

  • October 1999

publisher