Mapping the bovine homolog of the human cystic fibrosis gene. Academic Article

abstract

• Human cDNA probe H1.6 (clone 10-1) encoding cystic fibrosis transmembrane conductance regulator (CFTR) was used to map the bovine homolog of CFTR. Using a panel of bovine x rodent hybrid somatic cells, the homolog was mapped to bovine syntenic group U13 which corresponds to chromosome 4. CFTR is 97.7% concordant with syntenic markers T-cell receptor beta (TCRB) and P-glycoprotein 3 (PGY3). The comparative gene maps of CFTR, TCRB, and PGY3 on human chromosome 7, bovine chromosome 4, and mouse chromosome 5 and 6 indicate conservation of synteny, although internal rearrangements relative to HSA 7 are present in both cattle and mice.

authors

• Womack, James

published proceedings

• J Hered

author list (cited authors)

• Wallis, D., & Womack, J. E.

citation count

• 2

complete list of authors

• Wallis, D||Womack, JE

publication date

• November 1994

publisher

• Oxford University Press (OUP)  Publisher

published in

• JOURNAL OF HEREDITY  Journal

keywords

• Animals
• Cattle
• Chromosome Mapping
• Cystic Fibrosis
• Cystic Fibrosis Transmembrane Conductance Regulator
• DNA Probes
• DNA, Complementary
• Humans
• Hybrid Cells
• Membrane Proteins
• Mice

PubMed Central ID

• 7527809

Digital Object Identifier (DOI)

• 10.1093/oxfordjournals.jhered.a111508

start page

• 490

end page

• 492

volume

• 85

issue

• 6

URL

• http://dx.doi.org/10.1093/oxfordjournals.jhered.a111508