Somatic cell mapping of the bovine somatostatin gene. Academic Article

abstract

• DNAs from cow-hamster and cow-mouse hybrid somatic cells segregating cow chromosomes have been analyzed by Southern blotting and hybridization with a bovine somatostatin probe. The somatostatin gene (SST) was found to segregate concordantly with superoxide dismutase-1 (SOD1) and acrystallin (CRYA1), representing cattle syntenicsyntenic group U10. Because homologues of these three genes also have been mapped in mice and humans, a comparison of the gene maps of the three mammalian species gives some insight into the chromosomal rearrangements that have accompanied their evolution. We propose that the bovine chromosome carrying U10 is an ancestral hromosome that has given rise to human chromosome 21 and mouse chromosome 16, with each requiring a minimum of one rearrangement. 1989 The American Genetic Association.

authors

• Womack, James

published proceedings

• J Hered

author list (cited authors)

• Dietz, A. B., & Womack, J. E.

citation count

• 6

complete list of authors

• Dietz, AB||Womack, JE

publication date

• September 1989

publisher

• Oxford University Press (OUP)  Publisher

published in

• JOURNAL OF HEREDITY  Journal

keywords

• Animals
• Blotting, Southern
• Cattle
• Chromosome Mapping
• DNA Probes
• Genetic Markers
• Hybrid Cells
• Isoenzymes
• Somatostatin

PubMed Central ID

• 2571636

Digital Object Identifier (DOI)

• 10.1093/oxfordjournals.jhered.a110887

start page

• 410

end page

• 412

volume

• 80

issue

• 5

URL

• http://dx.doi.org/10.1093/oxfordjournals.jhered.a110887