Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.

abstract

• Cathelicidins (CATHLs) are small, cationic antimicrobial peptides that establish an early innate immune defense against infections in mammals. Beyond their wide spectrum of antimicrobial activity, these peptides play important roles in wound repair, chemotactic activity, and apoptosis. Thus, polymorphisms present in bovine CATHLs 2, 5, 6, and 7 could potentially underlie inherited differences in innate immunity and disease resistance. The purpose of the present study was to characterize single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family. Comparative sequence analysis for 10 domestic cattle breeds representing both Bos taurus and Bos indicus revealed 60 SNPs, 7 of which were nonsynonymous and 5 indel mutations. Characterization of these novel polymorphisms is central to developing a firm understanding regarding what effects, if any, nonsynonymous CATHL variation has with respect to bovine innate immunity.

authors

• Seabury, Christopher

published proceedings

• J Hered

altmetric score

• 3

author list (cited authors)

• Gillenwaters, E. N., Seabury, C. M., Elliott, J. S., & Womack, J. E.

citation count

• 10

complete list of authors

• Gillenwaters, Erin N||Seabury, Christopher M||Elliott, Janice S||Womack, James E

publication date

• March 2009

publisher

• Oxford University Press (OUP)  Publisher

published in

• JOURNAL OF HEREDITY  Journal

keywords

• Alleles
• Animals
• Antimicrobial Cationic Peptides
• Case-Control Studies
• Cathelicidins
• Cattle
• Gene Frequency
• Immunity, Innate
• Indel Mutation
• Multigene Family
• Point Mutation
• Polymorphism, Genetic
• Proteins
• Sequence Analysis, DNA

PubMed Central ID

• 19136450

Digital Object Identifier (DOI)

• 10.1093/jhered/esn112

start page

• 241

end page

• 245

volume

• 100

issue

• 2

URL

• http://dx.doi.org/10.1093/jhered/esn112