Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil. Academic Article uri icon


  • The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P less than 0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P less than 0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

published proceedings

  • Lipids

author list (cited authors)

  • Chapkin, R. S., Somers, S. D., Schumacher, L., & Erickson, K. L.

citation count

  • 24

complete list of authors

  • Chapkin, RS||Somers, SD||Schumacher, L||Erickson, KL

publication date

  • April 1988