Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil. Academic Article

abstract

• The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P less than 0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P less than 0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.

authors

• Chapkin, Robert

published proceedings

• Lipids

author list (cited authors)

• Chapkin, R. S., Somers, S. D., Schumacher, L., & Erickson, K. L.

citation count

• 24

complete list of authors

• Chapkin, RS||Somers, SD||Schumacher, L||Erickson, KL

publication date

• April 1988

publisher

• Wiley  Publisher

keywords

• Animals
• Dietary Fats
• Fatty Acids, Unsaturated
• Female
• Fish Oils
• Liver
• Macrophages
• Mice
• Mice, Inbred C57BL
• Oils
• Phospholipids
• Spleen

Digital Object Identifier (DOI)

• 10.1007/BF02537356

start page

• 380

end page

• 383

volume

• 23

issue

• 4

URL

• http://dx.doi.org/10.1007/bf02537356