Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. Academic Article

abstract

• Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress interleukin-2 (IL-2) secretion and impair T-lymphocyte proliferation. To determine the mechanism of action, mice were fed diets containing either safflower oil (control diet enriched in linoleic acid, 18:2n-6), EPA, DHA or arachidonic acid (20:4n-6). Splenic lymphocytes were isolated and concanavalin A-induced kinetics of IL-2 and IL-2 receptor alpha mRNA expression were determined by relative competitive-PCR. EPA and DHA did not affect IL-2 mRNA expression but suppressed IL-2 receptor alpha mRNA levels. These data show, for the first time, the selective effects of dietary EPA and DHA on T-lymphocyte gene expression.

authors

• Chapkin, Robert

published proceedings

• Prostaglandins Leukot Essent Fatty Acids

author list (cited authors)

• Jolly, C. A., McMurray, D. N., & Chapkin, R. S.

citation count

• 43

complete list of authors

• Jolly, CA||McMurray, DN||Chapkin, RS

publication date

• April 1998

publisher

• Elsevier  Publisher

published in

• Prostaglandins, Leukotrienes and Essential Fatty Acids  Journal

keywords

• Animals
• Arachidonic Acid
• Concanavalin A
• Dietary Fats, Unsaturated
• Docosahexaenoic Acids
• Eicosapentaenoic Acid
• Fatty Acids, Omega-3
• Female
• Gene Expression
• Interleukin-2
• Lymphocyte Activation
• Mice
• Mice, Inbred C57BL
• Mitogens
• RNA, Messenger
• Receptors, Interleukin-2
• Safflower Oil
• Specific Pathogen-Free Organisms
• T-Lymphocytes
• Time Factors

PubMed Central ID

• 9654402

Digital Object Identifier (DOI)

• 10.1016/s0952-3278(98)90038-2

start page

• 289

end page

• 293

volume

• 58

issue

• 4

URL

• http://dx.doi.org/10.1016/s0952-3278(98)90038-2