Modulation of atherogenesis by dietary gamma-linolenic acid. Academic Article

abstract

• Data from our in vitro studies indicate that macrophages isolated from mice fed GLA-enriched diets inhibit vascular SMC proliferation via a PGE1-cAMP dependent mechanism. Since SMC proliferation is one of the main events implicated in the pathogenesis of atherosclerosis (Ross, 1993), this anti-proliferative effect observed by dietary GLA is noteworthy. In vivo studies have established that dietary GLA is capable of retarding the atherosclerotic lesion formation in ApoE knock out mice, an animal model that develops atherosclerosis similar to humans (Reddick, 1994). We propose that dietary GLA has the potential to inhibit SMC proliferation leading to retardation of atherosclerotic lesion formation, and therefore favorable modulation of the atherogenic process.

authors

• Chapkin, Robert
• Ramos, Kenneth

published proceedings

• Adv Exp Med Biol

author list (cited authors)

• Fan, Y. Y., Ramos, K. S., & Chapkin, R. S.

citation count

• 8

complete list of authors

• Fan, YY||Ramos, KS||Chapkin, RS

publication date

• December 1999

publisher

• Springer Nature  Publisher

published in

• Advances in Experimental Medicine and Biology  Journal

keywords

• Alprostadil
• Animals
• Arteriosclerosis
• Cell Communication
• Cell Division
• Cells, Cultured
• Coculture Techniques
• Cyclic AMP
• DNA
• Dietary Fats, Unsaturated
• Gamma-linolenic Acid
• Humans
• Macrophages
• Mice
• Models, Biological
• Muscle, Smooth, Vascular

PubMed Central ID

• 10667372

Digital Object Identifier (DOI)

• 10.1007/978-1-4615-4793-8_71

start page

• 485

end page

• 491

volume

• 469

URL

• http://dx.doi.org/10.1007/978-1-4615-4793-8_71