Somatic cell mapping of bovine EC-SOD and SOD1L loci.

abstract

• cDNA probes of human extracellular superoxide dismutase (EC-SOD) and bovine superoxide dismutase 1 (SOD1) genes were hybridized to Southern blots containing genomic DNAs from cow-rodent somatic cell lines segregating bovine chromosomes. The SOD1 probe identified two loci: the coding locus (SOD1), which mapped to bovine U10; and a related locus (SOD1L), which mapped to U11. EC-SOD mapped to bovine U15. The mapping of EC-SOD to human chromosome 4, and our mapping of EC-SOD to U15, further defines a region of extensive syntenic conservation between humans and domestic cows.

published proceedings

• Genomics

author list (cited authors)

• Gallagher, D. S., Gibbs, L. S., Shaffer, J. B., & Womack, J. E.

citation count

• 7

complete list of authors

• Gallagher, DS||Gibbs, LS||Shaffer, JB||Womack, JE

publication date

• March 1992

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Animals
• Blotting, Southern
• Cattle
• Cell Line
• Chromosome Mapping
• DNA
• Humans
• Hybrid Cells
• Superoxide Dismutase

PubMed Central ID

• 1559712

Digital Object Identifier (DOI)

• 10.1016/0888-7543(92)90457-4

start page

• 610

end page

• 612

volume

• 12

issue

• 3

URL

• http://dx.doi.org/10.1016/0888-7543(92)90457-4