Regional localization of the fibronectin and gamma-crystallin genes to bovine chromosome 8. Academic Article

abstract

• The genes for isocitrate dehydrogenase-1, fibronectin, and gamma-crystallin are syntenic in man, mouse, and cow. In an effort to assign this bovine syntenic group to a specific chromosome and to allow a cytological comparison of the conserved chromosomal region containing these genes in their respective species, we have localized the fibronectin and gamma-crystallin genes to bovine chromosome 8, region 1.1-1.4. This study incorporates the techniques of hybrid somatic cell analysis and in situ hybridization and the use of a Robertsonian-translocated marker chromosome from a related species for regional assignment of genes to a specific bovine chromosome. The regions on human chromosome 2q, mouse chromosome 1, and cow chromosome 8 that contain these genes are cytologically similar, perhaps representing evolutionary conservation at the cytogenetic level as well as at the gene level for this group of loci.

authors

• Womack, James

published proceedings

• Genomics

author list (cited authors)

• Zneimer, S. M., & Womack, J. E.

citation count

• 4

complete list of authors

• Zneimer, SM||Womack, JE

publication date

• August 1989

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Animals
• Cattle
• Chromosome Banding
• Chromosome Mapping
• Crystallins
• DNA Probes
• Fibronectins
• Isocitrate Dehydrogenase
• Translocation, Genetic

PubMed Central ID

• 2793179

Digital Object Identifier (DOI)

• 10.1016/0888-7543(89)90049-9

start page

• 215

end page

• 220

volume

• 5

issue

• 2

URL

• http://dx.doi.org/10.1016/0888-7543(89)90049-9