Regional localization of the fibronectin and gamma-crystallin genes to bovine chromosome 8. Academic Article uri icon


  • The genes for isocitrate dehydrogenase-1, fibronectin, and gamma-crystallin are syntenic in man, mouse, and cow. In an effort to assign this bovine syntenic group to a specific chromosome and to allow a cytological comparison of the conserved chromosomal region containing these genes in their respective species, we have localized the fibronectin and gamma-crystallin genes to bovine chromosome 8, region 1.1-1.4. This study incorporates the techniques of hybrid somatic cell analysis and in situ hybridization and the use of a Robertsonian-translocated marker chromosome from a related species for regional assignment of genes to a specific bovine chromosome. The regions on human chromosome 2q, mouse chromosome 1, and cow chromosome 8 that contain these genes are cytologically similar, perhaps representing evolutionary conservation at the cytogenetic level as well as at the gene level for this group of loci.

published proceedings

  • Genomics

author list (cited authors)

  • Zneimer, S. M., & Womack, J. E.

citation count

  • 4

complete list of authors

  • Zneimer, SM||Womack, JE

publication date

  • August 1989