Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids. Academic Article

abstract

• Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and multifaceted, resulting in an incomplete understanding of their molecular mechanisms of action. Here, we focus on a highly conserved mechanism of n-3 PUFA, which is the alteration of the organization of the plasma membrane. We highlight recent work demonstrating that enrichment of n-3 PUFA in the plasma membrane alters the lateral organization of membrane signaling assemblies (i.e. lipid rafts). This mechanism is central for n-3 PUFA regulation of downstream signaling, T-cell activation, transcriptional activation, and cytokine secretion. We conclude that these studies provide strong evidence for a predominant mechanism by which n-3 PUFA function in colon cancer prevention.

authors

• Chapkin, Robert

published proceedings

• Prostaglandins Leukot Essent Fatty Acids

altmetric score

• 9.45

author list (cited authors)

• Turk, H. F., & Chapkin, R. S.

citation count

• 142

complete list of authors

• Turk, Harmony F||Chapkin, Robert S

publication date

• January 2013

publisher

• Elsevier  Publisher

published in

• Prostaglandins, Leukotrienes and Essential Fatty Acids  Journal

keywords

• Animals
• Anticarcinogenic Agents
• Colonic Neoplasms
• Dietary Supplements
• Fatty Acids, Omega-3
• Fish Oils
• Humans
• Membrane Microdomains
• Models, Biological
• Signal Transduction

PubMed Central ID

• 22515942

Digital Object Identifier (DOI)

• 10.1016/j.plefa.2012.03.008

start page

• 43

end page

• 47

volume

• 88

issue

• 1

URL

• http://dx.doi.org/10.1016/j.plefa.2012.03.008