selected publications academicarticle Zhang, H., Lu, Y., Kramer, P. R., Benson, M. D., Cheng, Y., & Qin, C. (2023). Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome. NEUROSCIENCE LETTERS. 802, 137176-137176. Barnts, K., Feng, J. Q., Qin, C., Zhang, H., & Cheng, Y. (2022). Adenomatoid odontogenic tumor: evidence for a mixed odontogenic tumor. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 133(6), 675-683. Zhang, H., Xu, Q., Lu, Y., & Qin, C. (2021). Effect of high phosphate diet on the formation of dentin in Fam20c-deficient mice. European Journal Of Oral Sciences. 129(3), e12795. Xu, Q., Zhang, H., Wang, S., Qin, C., & Lu, Y. (2021). Constitutive expression of spliced XBP1 causes perinatal lethality in mice. Genesis. 59(5-6), e23420. Jani, P., Zhang, H., Benson, M. D., & Qin, C. (2020). Noggin inhibition of mouse dentinogenesis. Journal of Oral Biosciences. 62(1), 72-79. Li, L., Saiyin, W., Zhang, H., Wang, S., Xu, Q., Qin, C., & Lu, Y. (2019). FAM20A is essential for amelogenesis, but is dispensable for dentinogenesis. 50(6), 581-591. Liang, T., Zhang, H., Xu, Q., Wang, S., Qin, C., & Lu, Y. (2019). Mutant Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta. Journal of Dental Research. 98(8), 912-919. Zhang, H., Li, L., Kesterke, M. J., Lu, Y., & Qin, C. (2019). High-Phosphate Diet Improved the Skeletal Development of Fam20c-Deficient Mice. Cells Tissues Organs. 208(1-2), 25-36. Saiyin, W., Li, L., Zhang, H., Lu, Y., & Qin, C. (2019). Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF- and MAPK signaling pathways. BBA: Molecular Basis of Disease. 1865(12), 165555-165555. Liu, X., Li, N., Zhang, H., Liu, J., Zhou, N., Ran, C., ... Liu, C. (2018). Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects. European Journal Of Oral Sciences. 126(5), 433-436. Liu, C., Zhang, H., Jani, P., Wang, X., Lu, Y., Li, N., Xiao, J., & Qin, C. (2018). FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner. Journal of Cellular Physiology. 233(4), 3476-3486. Liu, C., Zhou, N., Wang, Y. u., Zhang, H., Jani, P., Wang, X., ... Qin, C. (2018). Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells. Experimental Cell Research. 363(2), 188-195. Jani, P., Liu, C., Zhang, H., Younes, K., Benson, M. D., & Qin, C. (2018). The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis. Archives of Oral Biology. 90, 33-39. Zhang, H., Xie, X., Liu, P., Liang, T., Lu, Y., & Qin, C. (2018). Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS ONE. 13(4), e0195854-e0195854. Zhang, H., Jani, P., Liang, T., Lu, Y., & Qin, C. (2017). Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of Molecular Histology. 48(2), 83-98. Liu, P., Ma, S. u., Zhang, H., Liu, C., Lu, Y., Chen, L. i., & Qin, C. (2017). Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia. Scientific Reports. 7(1), 3590. Xie, X., Liu, C., Zhang, H., Jani, P. H., Lu, Y., Wang, X., Zhang, B., & Qin, C. (2016). Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression. Scientific Reports. 6(1), 25364. Jani, P. H., Gibson, M. P., Liu, C., Zhang, H., Wang, X., Lu, Y., & Qin, C. (2016). Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biology. 52-54, 95-112. Zhang, H., Liu, P., Wang, S., Liu, C., Jani, P., Lu, Y., & Qin, C. (2016). Transgenic expression of dentin phosphoprotein inhibits skeletal development. European Journal of Histochemistry. 60(1), 2587-54. Meng, T., Huang, Y., Wang, S., Zhang, H., Dechow, P. C., Wang, X., ... Lu, Y. (2015). Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. Journal of Biological Chemistry. 290(49), 29593-29602. Liu, C., Wang, X., Zhang, H., Xie, X., Liu, P., Liu, Y., ... Qin, C. (2015). Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics. Journal of Cellular Physiology. 230(11), 2581-2587. Feng, J. Q., Zhang, H., & Qin, C. (2015). Letter to the Editor, "Osterix Regulates Tooth Root Formation in a Site-specific Manner". Journal of Dental Research. 94(9), 1326-1326. Mobley, C. G., Kuzynski, M., Zhang, H., Jani, P., Qin, C., & Napierala, D. (2015). Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin Formation. Journal of Dental Research. 94(8), 1128-1134. Zhang, H., Jiang, Y., Qin, C., Liu, Y., Ho, S. P., & Feng, J. Q. (2015). Essential role of osterix for tooth root but not crown dentin formation. Journal of Bone and Mineral Research. 30(4), 742-746. Cao, Z., Liu, R., Zhang, H., Liao, H., Zhang, Y., Hinton, R. J., & Feng, J. Q. (2015). Osterix controls cementoblast differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression. International Journal of Biological Sciences. 11(3), 335-344. Liu, P., Zhang, H., Liu, C., Wang, X., Chen, L. i., & Qin, C. (2014). Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice. PLoS ONE. 9(12), e114396-e114396. Lin, S., Zhang, Q. i., Cao, Z., Lu, Y., Zhang, H., Yan, K., ... Feng, J. Q. (2014). Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. Journal of Biological Chemistry. 289(31), 21533-21543. Huang, Y., Meng, T., Wang, S., Zhang, H., Mues, G., Qin, C., ... Lu, Y. (2014). Twist1- and Twist2-haploinsufficiency results in reduced bone formation. PLoS ONE. 9(6), e99331-e99331. Chen, S., Feng, J., Zhang, H., Jia, M., Shen, Y., & Zong, Z. (2014). Key role for the transcriptional factor, osterix, in spine development. The Spine Journal. 14(4), 683-694. Lin, S., Zhang, Q. i., Zhang, H., Yan, K., Ward, L., Lu, Y., & Feng, J. (2014). Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice. International Journal of Oral Science. 6(3), 133-141. Cao, Z., Zhang, H., Zhou, X., Han, X., Ren, Y., Gao, T., ... Feng, J. Q. (2012). Genetic evidence for the vital function of Osterix in cementogenesis. Journal of Bone and Mineral Research. 27(5), 1080-1092. Zhang, H., Tian, Z., & Wang, J. (2010). Behavioral evaluation of transgenic mice with CNS expression of IFN-alpha by elevated plus-maze and Porsolt swim test. 479(3), 287-291. Wang, J., Dunn, A. J., Roberts, A. J., & Zhang, H. (2009). Decreased immobility in swimming test by homologous interferon-alpha in mice accompanied with increased cerebral tryptophan level and serotonin turnover. 452(2), 96-100. Wang, J., Campbell, I. L., & Zhang, H. (2008). Systemic interferon-alpha regulates interferon-stimulated genes in the central nervous system. 13(3), 293-301. Zhao, P., Ji, X., Zhang, H., Jiang, T., & Sun, X. (2001). [Gene rearrangement and p53 expression in defining the nature of angioimmunoblastic lymphadenopathy]. Zhonghua bing li xue za zhi Chinese journal of pathology. 30(2), 85-88.
education and training Ph.D. in Pharmacology/Molecular Biology & Biochemistry, Xi'an University of Posts and Telecommunications - (Xi'an, China) 2010 M.S. in Medical Pathology, Qingdao University - (Qingdao, China) 1997 M.D. in Medicine, Qingdao University - (Qingdao, China) 1994 Texas A&M Health Science Center - (College Station, Texas, United States) , Postdoctoral Training 2016
mailing address Texas A&M University College of Dentistry Biomedical Sciences 3302 Gaston Avenue Dallas, TX 75246 USA