DNA mutation detection and analysis using miniaturized microfluidic systems. Academic Article

abstract

• Identification of genetic sequence variations occurring on a population-wide scale is key to unraveling the complex interactions that are the underlying cause of many medical disorders and diseases. A critical need exists, however, for advanced technology to enable DNA mutation analysis to be performed with significantly higher throughput and at significantly lower cost than is currently attainable. Microfluidic systems offer an attractive platform to address these needs by combining the ability to perform rapid analysis with a simplified device format that can be inexpensively mass-produced. This paper will review recent progress toward developing these next-generation systems and discuss challenges associated with adapting these technologies for routine laboratory use.

authors

• Ugaz, Victor

published proceedings

• Expert Rev Mol Diagn

altmetric score

• 3

author list (cited authors)

• Handal, M. I., & Ugaz, V. M.

citation count

• 17

complete list of authors

• Handal, Maria I||Ugaz, Victor M

publication date

• January 2006

publisher

• Taylor & Francis  Publisher

published in

• Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare  Journal

keywords

• DNA Mutational Analysis
• Humans
• Microfluidics
• Miniaturization
• Molecular Diagnostic Techniques
• Mutation
• Polymorphism, Genetic

PubMed Central ID

• 16359265

Digital Object Identifier (DOI)

• 10.1586/14737159.6.1.29

start page

• 29

end page

• 38

volume

• 6

issue

• 1

URL

• http://dx.doi.org/10.1586/14737159.6.1.29