Polymerase chain reaction in miniaturized systems: big progress in little devices. Academic Article uri icon


  • A critical need exists for advanced technologies that enable genomic-based DNA analysis to be performed with significantly higher throughput and at a significantly lower cost than is attainable with current hardware. Miniaturized polymerase chain reaction systems offer an attractive platform to address these needs, combining the ability to perform rapid thermocycling with a portable device format that can be inexpensively mass produced. We review recent efforts aimed at developing these next-generation systems and discuss some of the practical considerations involved in adapting this technology for routine laboratory use.

published proceedings

  • Methods Mol Biol

author list (cited authors)

  • Spitzack, K. D., & Ugaz, V. M.

citation count

  • 4

complete list of authors

  • Spitzack, Kalee D||Ugaz, Victor M

publication date

  • January 2006