Polymerase chain reaction in miniaturized systems: big progress in little devices.
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A critical need exists for advanced technologies that enable genomic-based DNA analysis to be performed with significantly higher throughput and at a significantly lower cost than is attainable with current hardware. Miniaturized polymerase chain reaction systems offer an attractive platform to address these needs, combining the ability to perform rapid thermocycling with a portable device format that can be inexpensively mass produced. We review recent efforts aimed at developing these next-generation systems and discuss some of the practical considerations involved in adapting this technology for routine laboratory use.
author list (cited authors)
Spitzack, K. D., & Ugaz, V. M.
complete list of authors
Spitzack, Kalee D||Ugaz, Victor M