Tailoring the nanoporous architecture of hydrogels to exploit entropic trapping. Academic Article uri icon


  • Macromolecules embedded in a nanoporous matrix display anomalous transport behavior in the entropic trapping regime. But these phenomena have not been widely explored in hydrogel matrices because it has not been clear how to link them to the underlying heterogeneous nanopore morphology. Here we introduce a theoretical model that establishes this connection and describe microchip DNA electrophoresis experiments that demonstrate how entropic trapping effects can be exploited to yield a trend of increasing resolving power with DNA size (the opposite of what is conventionally observed).

published proceedings

  • Phys Rev Lett

author list (cited authors)

  • Shi, N., & Ugaz, V. M.

citation count

  • 8

complete list of authors

  • Shi, Nan||Ugaz, Victor M

publication date

  • September 2010