Smartphone-based detection of unlabeled DNA via electrochemical dissolution. Academic Article

abstract

• We describe a novel approach that enables unlabeled biomolecules and chemical analytes to be detected using ordinary smartphone optics. Electrochemical reactivity of chromium, ordinarily considered detrimental, is harnessed here to generate a signature that can be easily seen by monitoring electrode dissolution under ordinary white-light illumination. The simplicity and robustness of this approach eliminates the need for labeling and/or pre-programming with specific receptors (e.g., oligonucleotide probes), making it feasible to greatly expand availability of a host of assays where detection complexity is a limiting constraint.

authors

• Ugaz, Victor

published proceedings

• Analyst

author list (cited authors)

• Huang, Y., & Ugaz, V. M.

citation count

• 15

complete list of authors

• Huang, Yu-Wen||Ugaz, Victor M

publication date

• May 2013

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• The Analyst  Journal

keywords

• Cell Phone
• Chromium
• DNA
• Electrochemical Techniques
• Electrodes
• Equipment Failure
• Polymerase Chain Reaction

PubMed Central ID

• 23476923

Digital Object Identifier (DOI)

• 10.1039/c3an36875k

start page

• 2522

end page

• 2526

volume

• 138

issue

• 9