Synteny mapping of the genes for 21 steroid hydroxylase, alpha A crystallin, and class I bovine leukocyte antigen in cattle. Academic Article

abstract

• Synteny mapping of the genes for bovine alpha A crystallin (CRYA-1), steroid 21 hydroxylase (21OH), and a class I major histocompatibility locus bovine leukocyte antigen (BoLA) was accomplished by Southern blot analysis of DNA from bovine-hamster hybrid somatic cells. Comparison of the distribution patterns of CRYA-1, 21OH, and BoLA sequences among the hybrid cells revealed that the genes are located on two different chromosomes in the bovine genome. CRYA-1 mapped with superoxide dismutase (SOD1 in syntenic group U10, while 21OH and BoLA were concordant with glyoxylase (GLO1) in syntenic group U21. Therefore, the syntenic array of CRYA-1, 21OH, and BoLA in cattle is different from that observed in rodents, where the genes are closely linked to each other and to GLO1, and consistent with reported linkages in man.

authors

• Skow, Loren
• Womack, James

published proceedings

• DNA

author list (cited authors)

• Skow, L. C., Womack, J. E., Petresh, J. M., & Miller, W. L.

citation count

• 40

complete list of authors

• Skow, LC||Womack, JE||Petresh, JM||Miller, WL

publication date

• April 1988

publisher

• Mary Ann Liebert  Publisher

published in

• DNA and Cell Biology  Journal

keywords

• Animals
• Antigens, Differentiation
• Cattle
• Chromosome Mapping
• Cricetinae
• Cricetulus
• Crystallins
• Genes
• Genes, MHC Class I
• Histocompatibility Antigens
• Hybrid Cells
• Leukocyte Common Antigens
• Nucleic Acid Hybridization
• Steroid 21-hydroxylase
• Steroid Hydroxylases

PubMed Central ID

• 2967168

Digital Object Identifier (DOI)

• 10.1089/dna.1988.7.143

start page

• 143

end page

• 149

volume

• 7

issue

• 3

URL

• http://dx.doi.org/10.1089/dna.1988.7.143