Basic determinants of epicardial transudation
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Myocardial edema formation, which has been shown to compromise cardiac function, and increased epicardiâl transudation (pericardial effusion) have been shown to occur after elevation of myocardial venous and lymphatic outflow pressures. The purposes of this study were to estimate the hydraulic conductance and osmotic reflection coefficient for the epicardium and to determine the effect of coronary sinus hypertension and cardiac lymphatic obstruction on epicardiâl fluid flux (J v,e /A e ). A Plexiglas hemispheric capsule was attached to the left ventricular epicardiâl surface of anesthetized dogs. J V,e /A e was determined over 30-min periods for three intracapsular pressures (-5, -15, and -25 mmHg) and two intracapsular solutions exerting colloid osmotic pressures of 7.0 and 2.0 mmHg. Hydraulic conductance was estimated to be 3.7 ±0.5 μl·h -1 ·cm -2 ·mmHg -1 . An osmotic reflection coefficient of 0.9 was calculated from the difference in J V,e /A e of 16.5 ±8.4 μl·h -1 ·cm -2 between the two solutions. Graded coronary sinus hypertension induced a linear increase in J V,e /A e , which was significantly greater in dogs without cardiac lymphatic occlusion than in those with occlusion. Copyright ©1997 the American Physiological Society.
author list (cited authors)
Stewart, R. H., Rohn, D. A., Allen, S. J., & Laine, G. A.