Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus. Academic Article uri icon

abstract

  • Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.

published proceedings

  • Nephrol Dial Transplant

author list (cited authors)

  • Kadikoy, H., Paolini, M., Achkar, K., Suki, W., Gaber, A. O., Anwar, N., ... Abdellatif, A.

citation count

  • 23

complete list of authors

  • Kadikoy, Huseyin||Paolini, Michael||Achkar, Katafan||Suki, Wadi||Gaber, A Osama||Anwar, Nabeel||Jeroudi, Abdallah||Barrios, Roberto||Abdellatif, Abdul

publication date

  • August 2010