Chemotherapeutic Properties of n-3 Polyunsaturated Fatty Acids - Old Concepts and New Insights.

abstract

• Over the past several decades, data from both experimental animal studies and human clinical trials have shown that dietary n-3 polyunsaturated fatty acids (PUFA) exhibit anti-inflammatory bioactive properties, compared to n-6 PUFA. Collectively, these studies have identified multiple mechanisms by which n-3 PUFA affect immune cell responses. In this review, we discuss the putative targets of anti-inflammatory n-3 PUFA, specifically, cytokine production, antagonism of n-6 PUFA metabolism, binding to nuclear receptors as ligands, and the alteration of signaling protein acylation. In addition, we investigate the effect of n-3 PUFA on the coalescence of lipid rafts, specialized signaling platforms in the plasma membrane.

authors

• Chapkin, Robert

published proceedings

• Immunol Endocr Metab Agents Med Chem

author list (cited authors)

• Kim, W., McMurray, D. N., & Chapkin, R. S.

citation count

• 9

complete list of authors

• Kim, Wooki||McMurray, David N||Chapkin, Robert S

publication date

• March 2009

publisher

• BENTHAM SCIENCE PUBLISHERS  Publisher

published in

• Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry  Journal

keywords

• Complementary And Integrative Health
• Inflammatory And Immune System
• Nutrition

PubMed Central ID

• 19823600

Digital Object Identifier (DOI)

• 10.2174/187152209788009841

start page

• 38

end page

• 44

volume

• 9

issue

• 1

URL

• http://dx.doi.org/10.2174/187152209788009841