A micro-aspirator chip using vacuum expanded microchannels for high-throughput mechanical characterization of biological cells
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abstract
Mechanical properties of cells can serve as biomarkers to identify cells depending on their disease states, and thus have the potential to be used in disease diagnostic applications. However, existing techniques are not capable of quantifying these properties in statistically significant quantities. To address this, we propose a high-throughput micro-aspirator chip, which can deliver, trap, and deform multiple cells simultaneously at single-cell resolution without skill-dependent micromanipulation. The mechanical property of HeLa cells was measured using the micro-aspirator chip and no dependency of HeLa cell Young's modulus on the diameter of the cells was found.
