Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Academic Article uri icon

abstract

  • Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.

published proceedings

  • Nat Genet

altmetric score

  • 1249.704

author list (cited authors)

  • Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.

citation count

  • 1930

complete list of authors

  • Wray, Naomi R||Ripke, Stephan||Mattheisen, Manuel||Trzaskowski, Maciej||Byrne, Enda M||Abdellaoui, Abdel||Adams, Mark J||Agerbo, Esben||Air, Tracy M||Andlauer, Till MF||Bacanu, Silviu-Alin||Bækvad-Hansen, Marie||Beekman, Aartjan FT||Bigdeli, Tim B||Binder, Elisabeth B||Blackwood, Douglas RH||Bryois, Julien||Buttenschøn, Henriette N||Bybjerg-Grauholm, Jonas||Cai, Na||Castelao, Enrique||Christensen, Jane Hvarregaard||Clarke, Toni-Kim||Coleman, Jonathan IR||Colodro-Conde, Lucía||Couvy-Duchesne, Baptiste||Craddock, Nick||Crawford, Gregory E||Crowley, Cheynna A||Dashti, Hassan S||Davies, Gail||Deary, Ian J||Degenhardt, Franziska||Derks, Eske M||Direk, Nese||Dolan, Conor V||Dunn, Erin C||Eley, Thalia C||Eriksson, Nicholas||Escott-Price, Valentina||Kiadeh, Farnush Hassan Farhadi||Finucane, Hilary K||Forstner, Andreas J||Frank, Josef||Gaspar, Héléna A||Gill, Michael||Giusti-Rodríguez, Paola||Goes, Fernando S||Gordon, Scott D||Grove, Jakob||Hall, Lynsey S||Hannon, Eilis||Hansen, Christine Søholm||Hansen, Thomas F||Herms, Stefan||Hickie, Ian B||Hoffmann, Per||Homuth, Georg||Horn, Carsten||Hottenga, Jouke-Jan||Hougaard, David M||Hu, Ming||Hyde, Craig L||Ising, Marcus||Jansen, Rick||Jin, Fulai||Jorgenson, Eric||Knowles, James A||Kohane, Isaac S||Kraft, Julia||Kretzschmar, Warren W||Krogh, Jesper||Kutalik, Zoltán||Lane, Jacqueline M||Li, Yihan||Li, Yun||Lind, Penelope A||Liu, Xiaoxiao||Lu, Leina||MacIntyre, Donald J||MacKinnon, Dean F||Maier, Robert M||Maier, Wolfgang||Marchini, Jonathan||Mbarek, Hamdi||McGrath, Patrick||McGuffin, Peter||Medland, Sarah E||Mehta, Divya||Middeldorp, Christel M||Mihailov, Evelin||Milaneschi, Yuri||Milani, Lili||Mill, Jonathan||Mondimore, Francis M||Montgomery, Grant W||Mostafavi, Sara||Mullins, Niamh||Nauck, Matthias||Ng, Bernard||Nivard, Michel G||Nyholt, Dale R||O'Reilly, Paul F||Oskarsson, Hogni||Owen, Michael J||Painter, Jodie N||Pedersen, Carsten Bøcker||Pedersen, Marianne Giørtz||Peterson, Roseann E||Pettersson, Erik||Peyrot, Wouter J||Pistis, Giorgio||Posthuma, Danielle||Purcell, Shaun M||Quiroz, Jorge A||Qvist, Per||Rice, John P||Riley, Brien P||Rivera, Margarita||Saeed Mirza, Saira||Saxena, Richa||Schoevers, Robert||Schulte, Eva C||Shen, Ling||Shi, Jianxin||Shyn, Stanley I||Sigurdsson, Engilbert||Sinnamon, Grant BC||Smit, Johannes H||Smith, Daniel J||Stefansson, Hreinn||Steinberg, Stacy||Stockmeier, Craig A||Streit, Fabian||Strohmaier, Jana||Tansey, Katherine E||Teismann, Henning||Teumer, Alexander||Thompson, Wesley||Thomson, Pippa A||Thorgeirsson, Thorgeir E||Tian, Chao||Traylor, Matthew||Treutlein, Jens||Trubetskoy, Vassily||Uitterlinden, André G||Umbricht, Daniel||Van der Auwera, Sandra||van Hemert, Albert M||Viktorin, Alexander||Visscher, Peter M||Wang, Yunpeng||Webb, Bradley T||Weinsheimer, Shantel Marie||Wellmann, Jürgen||Willemsen, Gonneke||Witt, Stephanie H||Wu, Yang||Xi, Hualin S||Yang, Jian||Zhang, Futao||Arolt, Volker||Baune, Bernhard T||Berger, Klaus||Boomsma, Dorret I||Cichon, Sven||Dannlowski, Udo||de Geus, ECJ||DePaulo, J Raymond||Domenici, Enrico||Domschke, Katharina||Esko, Tõnu||Grabe, Hans J||Hamilton, Steven P||Hayward, Caroline||Heath, Andrew C||Hinds, David A||Kendler, Kenneth S||Kloiber, Stefan||Lewis, Glyn||Li, Qingqin S||Lucae, Susanne||Madden, Pamela FA||Magnusson, Patrik K||Martin, Nicholas G||McIntosh, Andrew M||Metspalu, Andres||Mors, Ole||Mortensen, Preben Bo||Müller-Myhsok, Bertram||Nordentoft, Merete||Nöthen, Markus M||O'Donovan, Michael C||Paciga, Sara A||Pedersen, Nancy L||Penninx, Brenda WJH||Perlis, Roy H||Porteous, David J||Potash, James B||Preisig, Martin||Rietschel, Marcella||Schaefer, Catherine||Schulze, Thomas G||Smoller, Jordan W||Stefansson, Kari||Tiemeier, Henning||Uher, Rudolf||Völzke, Henry||Weissman, Myrna M||Werge, Thomas||Winslow, Ashley R||Lewis, Cathryn M||Levinson, Douglas F||Breen, Gerome||Børglum, Anders D||Sullivan, Patrick F

publication date

  • May 2018