A para-C-H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents Academic Article

abstract

• A practical paraCH functionalization of aniline derivatives has been developed using an in situ generated bulky hypervalent iodinium reagent. Paraiodo, bromo, chloro, nitro, trifluormethyl aniline derivatives can be obtained efficiently, in many cases in 10 min in a transition metalfree manner. Medicinal chemicals or intermediates can be purified without column chromatography or recrystallization, which significantly reduces the waste and simplifies the workup process.

authors

• Tian, Chao

published proceedings

• EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

altmetric score

• 1.25

author list (cited authors)

• Tian, C., Yao, X. u., Ji, W., Wang, Q., An, G., & Li, G.

citation count

• 42

complete list of authors

• Tian, Chao||Yao, Xu||Ji, Weizhe||Wang, Qian||An, Guanghui||Li, Guangming

publication date

• November 2018

publisher

• Wiley  Publisher

published in

• European Journal of Organic Chemistry  Journal

keywords

• Arenes
• C-h Activation
• Hypervalent Iodinium Reagents
• Iodine-mediated Reactions
• Reaction Mechanisms
• Steric Control

Digital Object Identifier (DOI)

• 10.1002/ejoc.201801058

start page

• 5972

end page

• 5979

volume

• 2018

issue

• 43

URL

• http://dx.doi.org/10.1002/ejoc.201801058