A Metal-Free Three-Component Reaction of trans--Nitrostyrene Derivatives, Dibromo Amides, and Amines Leading to Functionalized Amidines. Academic Article uri icon


  • A mild, metal-free, and multicomponent route for the preparation of N-acyl amidines from nitroalkene derivatives, dibromo amides, and amines has been developed that accesses an initial ,-dibromonitroalkane intermediate that can undergo C-C bond cleavage. This protocol offers an alternative approach toward N-acyl amidines and features the rapid construction of amidine frameworks with high diversity and complexity. The procedure also accesses bisamidine and ,-unsaturated amidines which are challenging targets by traditional methods.

published proceedings

  • J Org Chem

author list (cited authors)

  • Zhou, M., Li, J., Tian, C., Sun, X., Zhu, X., Cheng, Y., An, G., & Li, G.

citation count

  • 16

complete list of authors

  • Zhou, Meng||Li, Jinlei||Tian, Chao||Sun, Xiao||Zhu, Xiaoting||Cheng, Yaohang||An, Guanghui||Li, Guangming

publication date

  • January 2019