A Metal-Free Three-Component Reaction of trans--Nitrostyrene Derivatives, Dibromo Amides, and Amines Leading to Functionalized Amidines. Academic Article

abstract

• A mild, metal-free, and multicomponent route for the preparation of N-acyl amidines from nitroalkene derivatives, dibromo amides, and amines has been developed that accesses an initial ,-dibromonitroalkane intermediate that can undergo C-C bond cleavage. This protocol offers an alternative approach toward N-acyl amidines and features the rapid construction of amidine frameworks with high diversity and complexity. The procedure also accesses bisamidine and ,-unsaturated amidines which are challenging targets by traditional methods.

authors

• Tian, Chao

published proceedings

• J Org Chem

author list (cited authors)

• Zhou, M., Li, J., Tian, C., Sun, X., Zhu, X., Cheng, Y., An, G., & Li, G.

citation count

• 16

complete list of authors

• Zhou, Meng||Li, Jinlei||Tian, Chao||Sun, Xiao||Zhu, Xiaoting||Cheng, Yaohang||An, Guanghui||Li, Guangming

publication date

• January 2019

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of Organic Chemistry  Journal

PubMed Central ID

• 30592406

Digital Object Identifier (DOI)

• 10.1021/acs.joc.8b02998

start page

• 1015

end page

• 1024

volume

• 84

issue

• 2

URL

• http://dx.doi.org/10.1021/acs.joc.8b02998