A hydrate salt-promoted reductive coupling reaction of nitrodienes with unactivated alkenes. Academic Article

abstract

• Transition metal-catalyzed reductive coupling has emerged as a powerful method for the construction of C-C bonds. Herein, a crystalline hydrate, Na2HPO47H2O, has been disclosed as an effective promoter for the reductive coupling of nitrodienes with unactivated alkenes to afford diverse dienes with various functionalities in an open-flask manner. The mechanism study has revealed that Na2HPO47H2O accelerates the in situ generation of active silane PhSi(OEt)H2 and prevents the deactivation of catalyst. The approach can increase the efficiency of previous reductive coupling reactions as well.

authors

• Tian, Chao

published proceedings

• Org Biomol Chem

author list (cited authors)

• Zhang, M., Yang, L., Tian, C., Zhou, M., An, G., & Li, G.

citation count

• 13

complete list of authors

• Zhang, Mengmeng||Yang, Liming||Tian, Chao||Zhou, Meng||An, Guanghui||Li, Guangming

publication date

• February 2019

publisher

• Royal Society of Chemistry (RSC)  Publisher

published in

• Organic and Biomolecular Chemistry  Journal

PubMed Central ID

• 30724308

Digital Object Identifier (DOI)

• 10.1039/c9ob00136k

start page

• 2258

end page

• 2264

volume

• 17

issue

• 8

URL

• http://dx.doi.org/10.1039/c9ob00136k