Palladium-Catalyzed C-H Arylation of Aliphatic and Aromatic Ketones using Dipeptide Transient Directing Groups Academic Article

abstract

• AbstractKetones are ubiquitous structural motifs in chemical materials and medicinally active pharmaceutical ingredients. Transition metalcatalyzed CH bond functionalization is one of the most efficient tactics for diversification of ketones. Palladiumcatalyzed CH arylation of aliphatic and aromatic ketones has been achieved utilizing an inexpensive dipeptide as a transient directing group. The tridentate coordination used in this reaction enhances the reactivity of the substrates and allows reduction of the loading of the directing group compounds to 20%. This approach allows rapid arylation of complex natural products, medicinalchemistryrelated scaffolds, and even remote C(sp2)H bonds.

authors

• Tian, Chao

published proceedings

• ASIAN JOURNAL OF ORGANIC CHEMISTRY

altmetric score

• 0.5

author list (cited authors)

• Cheng, Y., Zheng, J., Tian, C., He, Y., Zhang, C., Tan, Q. i., An, G., & Li, G.

citation count

• 27

publication date

• April 2019

publisher

• Wiley  Publisher

keywords

• Arylation
• C-h Activation
• Ketones
• Peptides
• Tridentate Coordination

Digital Object Identifier (DOI)

• 10.1002/ajoc.201900037

start page

• 526

end page

• 531

volume

• 8

issue

• 4

URL

• http://dx.doi.org/10.1002/ajoc.201900037