Visible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives. Academic Article uri icon


  • A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the "CF3" source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives.

published proceedings

  • J Org Chem

author list (cited authors)

  • Tian, C., Wang, Q., Wang, X., An, G., & Li, G.

citation count

  • 44

complete list of authors

  • Tian, Chao||Wang, Qiyue||Wang, Xueqi||An, Guanghui||Li, Guangming

publication date

  • November 2019