Assessing Orofacial Pain Behaviors in Animal Models: A Review. Academic Article

abstract

• Orofacial pain refers to pain occurring in the head and face, which is highly prevalent and represents a challenge to clinicians, but its underlying mechanisms are not fully understood, and more studies using animal models are urgently needed. Currently, there are different assessment methods for analyzing orofacial pain behaviors in animal models. In order to minimize the number of animals used and maximize animal welfare, selecting appropriate assessment methods can avoid repeated testing and improve the reliability and accuracy of research data. Here, we summarize different methods for assessing spontaneous pain, evoked pain, and relevant accompanying dysfunction, and discuss their advantages and disadvantages. While the behaviors of orofacial pain in rodents are not exactly equivalent to the symptoms displayed in patients with orofacial pain, animal models and pain behavioral assessments have advanced our understanding of the pathogenesis of such pain.

authors

• Tao, Feng

published proceedings

• Brain Sci

author list (cited authors)

• Liu, S., Crawford, J., & Tao, F.

citation count

• 0

complete list of authors

• Liu, Sufang||Crawford, Joshua||Tao, Feng

publication date

• February 2023

publisher

• MDPI  Publisher

published in

• Brain Sciences  Journal

keywords

• Animal Models
• Behavioral Testing
• Evoked Pain
• Ongoing Pain
• Orofacial Pain
• Rodents
• Spontaneous Pain

PubMed Central ID

• 36979200

Digital Object Identifier (DOI)

• 10.3390/brainsci13030390

start page

• 390

end page

• 390

volume

• 13

issue

• 3

URL

• http://dx.doi.org/10.3390/brainsci13030390