Development of a Model for Use in Pharmaceutical Trials: Induced Pasteurella Pneumonia and Body Temperature Telemetry in Weaned Beef Calves Academic Article uri icon

abstract

  • The most common method for inducing pneumonicpasteurellosis in cattle for the study of therapeutic andimmunologic interventions is to instill fresh live culturesof Pasteurella haemolytica into the trachea, into mainstem bronchi, or into the thoracic cavity percutaneously(transthoracic). Evaluating therapeutic outcome may includecomparisons of clinical recovery, mortality, weightgain, or other response variables. Our initial efforts to induce pneumonia in beef calves utilizing a model previously validated in neonatal dairy calves produced inconsistent results. In order to use the model in pharmacotherapeutic trials, disease must be reliably produced. We were interested in developing a model for induction of pneumonia in weaned beef calves (approximately 400 lbs.) so that differences in body temperature, lung consolidation and neutrophil function could be used to compare antimicrobial therapies.

published proceedings

  • Annual convention proceedings

author list (cited authors)

  • Fajt, V. R., Apley, M. D., Brogden, K. A., & Skogerboe, T.

citation count

  • 1

publication date

  • September 1999