Fundamental Investigations of the Mechanism of Laser Desorption and Ionization in Matrix Assisted Laser Desorption / Ionization Conference Paper uri icon

abstract

  • The recent development of Matrix Assisted Laser Desorption / Ionization (MALDI) has sparked a revolution in the field of high molecular weight mass spectrometry.1 Time-of-flight (TOF) mass spectra of proteins weighing up to 300,000 Da are now routinely produced and this achievement has fostered a variety of bioanalytical applications which were previously unapproachable using conventional mass spectrometric techniques. These successful applications have burgeoned in spite of a poor understanding of the mechanism of analyte desorption and ionization under MALDI conditions. An improved understanding of the MALDI mechanism should aid in overcoming a number of limitations of the current state-of-the-art and forms the motivation for the work described.

name of conference

  • Laser Applications to Chemical Analysis

published proceedings

  • Laser Applications to Chemical Analysis

author list (cited authors)

  • Kinsel, G. R., Gillig, K., Edmondson, R., & Russell, D. H.

citation count

  • 0

complete list of authors

  • Kinsel, Gary R||Gillig, Kent||Edmondson, Ricky||Russell, David H

publication date

  • January 1994