The Emerging Role of Biological Sex in Cell Therapy for Spinal Cord Injury. Academic Article

abstract

• Neural progenitor cell (NPC) transplantation is a promising potential therapy for replacing spinal cord neurons and glial cells following spinal cord injury (SCI). Despite the rapid advancement of NPC transplantation to SCI clinical trials, we still lack understanding of fundamental biology underlying how NPC grafts interact with the injured host nervous system. Our recent study demonstrated a potent effect of biological sex mismatch between donor and host on graft immune rejection. Here we discuss the implications of this study in the context of clinical trials for SCI, and important topics for future research in SCI cell transplantation.

authors

• Dulin, Jennifer

published proceedings

• Neurosci Insights

altmetric score

• 2.1

author list (cited authors)

• Tucker, A., & Dulin, J. N.

citation count

• 0

complete list of authors

• Tucker, Ashley||Dulin, Jennifer N

publication date

• January 2023

publisher

• SAGE Publications  Publisher

published in

• Neuroscience Insights  Journal

keywords

• Clinical Trials
• Graft Rejection
• Neural Progenitor Cell Transplantation
• Sex Mismatch

PubMed Central ID

• 36798608

Digital Object Identifier (DOI)

• 10.1177/26331055231153128

start page

• 26331055231153128

end page

• 263310552311531

volume

• 18

URL

• http://dx.doi.org/10.1177/26331055231153128