Sphingolipids in obesity and related complications. Academic Article

abstract

• Sphingolipids are biologically active lipids ubiquitously produced in all vertebrate cells. Asides from structural components of cell membrane, sphingolipids also function as intracellular and extracellular mediators that regulate many important physiological cellular processes including cell survival, proliferation, apoptosis, differentiation, migration and immune processes. Recent studies have also indicated that disruption of sphingolipid metabolism is strongly associated with different diseases that exhibit diverse neurological and metabolic consequences. Here, we briefly summarize current evidence for understanding of sphingolipid pathways in obesity and associated complications. The regulation of sphingolipids and their enzymes may have a great impact in the development of novel therapeutic modalities for a variety of metabolic diseases.

authors

• Koka, Sai

published proceedings

• Front Biosci (Landmark Ed)

altmetric score

• 2.5

author list (cited authors)

• Boini, K. M., Xia, M., Koka, S., Gehr, T., & Li, P.

citation count

• 32

complete list of authors

• Boini, Krishna M||Xia, Min||Koka, Saisudha||Gehr, Todd WB||Li, Pin-Lan

publication date

• January 2017

publisher

• IMR Press  Publisher

published in

• Frontiers in Bioscience  Journal

keywords

• Adipokines
• Adipose Tissue
• Animals
• Atherosclerosis
• Diabetes Mellitus
• Energy Intake
• Humans
• Hypertension
• Inflammasomes
• Insulin Resistance
• Obesity
• Oxidative Stress
• Renal Insufficiency, Chronic
• Sphingolipids

Digital Object Identifier (DOI)

• 10.2741/4474

start page

• 96

end page

• 116

volume

• 22

issue

• 1

URL

• http://dx.doi.org/10.2741/4474