HR job title
- Associate Professor
- Contact Info
- ORCiD
- 0000-0002-3193-6923
Clark, Shaunna Associate Professor
Positions
- Associate Professor, Psychiatry and Behavioral Sciences, School of Medicine
Dr. Clark's research seeks to understand how biological and environmental factors shape substance use and addiction. Specifically, the lab focuses on the role of genetics and epigenetics in the etiology of substance use and addiction and identifying (epi)genetic biomarkers. This line of research will eventually lead to the improvement of diagnosis, prognosis and treatment of substance addiction and its related health effects. We approach these research questions using a translational framework that incorporates both human and animal studies, big data, and advanced statistical modeling techniques.
- Overview
- Publications
- Research
- Teaching
- Background
- Contact
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Overview
Publications
selected publications
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academic article
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Ingram, S. J., Vazquez, A. Y., Klump, K. L., Hyde, L. W., Burt, S. A., & Clark, S. L.
(2024).
Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging. JOURNAL OF AFFECTIVE DISORDERS.
352, 250-258.
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White, J. D., Minto, M. S., Willis, C., Quach, B. C., Han, S., Tao, R., ... Hancock, D. B.
(2024).
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex
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Aksan, N., Guzick, A. G., Taylor, L., Richmond, R., Liberzon, I., Cross, J., ... Nemeroff, C. B.
(2024).
Evaluating traumatic event scoring schemas for their predictive value to concurrent diagnostic profiles: Texas Childhood Trauma Research Network. 345, 94-102.
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Clark, S. L., McGinnis, E. W., Zhao, M., Xie, L., Marks, G. T., Aberg, K. A., van den Oord, E., & Copeland, W. E.
(2023).
The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood. S0890-8567(23)02266-9.
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Clark, S. L., Dodd, C. G., Taylor, L., Stewart, S., Yang, N., Shahidullah, J. D., ... Nemeroff, C. B.
(2023).
Characterizing patterns of substance use in trauma exposed youth. 167, 1-9.
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Hettema, J. M., van den Oord, E., Zhao, M., Xie, L. Y., Copeland, W. E., Penninx, B., Aberg, K. A., & Clark, S. L.
(2023).
Methylome-wide association study of anxiety disorders. Molecular Psychiatry.
28(8), 3484-3492.
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Clark, S., van den Oord, E., Zhao, M., Xie, L. Y., Copeland, B., Penninx, B., Aberg, K., & Hettema, J.
(2023).
Cell-Type Specific Methylome-Wide Association Study of Anxiety Disorders. Biological Psychiatry.
93(9), S68-S68.
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Gruber, J. A., Anderson-Carpenter, K. D., McNall, M., & Clark, S. L.
(2023).
Understanding the Longitudinal Impact of School-Based Health Centers on Student Attendance. Child and Youth Care Forum: an independent journal of day and residential child and youth care practice.
52(2), 331-350.
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Regan, T., McCredie, M. N., Harris, B., & Clark, S.
(2023).
Using classification trees to identify psychotherapy patients at risk for poor treatment adherence. Psychotherapy Research.
ahead-of-print(ahead-of-print), 1-12.
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Hettema, J., van den Oord, E., Zhao, M., Xie, L., Copeland, W., Penninx, B., Aberg, K., & Clark, S.
(2022).
METHYLOME-WIDE ASSOCIATION STUDY OF ANXIETY DISORDERS. European Neuropsychopharmacology.
63, E3-E3.
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Goodman-Williams, R., Clark, S. L., Campbell, R., & Ullman, S. E.
(2022).
Longitudinal patterns of posttraumatic stress disorder symptoms among sexual assault survivors: A latent transition analysis. Psychological Trauma.
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Guintivano, J., Aberg, K. A., Clark, S. L., Rubinow, D. R., Sullivan, P. F., Meltzer-Brody, S., & van den Oord, E.
(2022).
Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance. Molecular Psychiatry.
27(6), 2858-2867.
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Clark, S. L., Chan, R. F., Zhao, M., Xie, L. Y., Copeland, W. E., Penninx, B., Aberg, K. A., & van den Oord, E.
(2022).
Dual methylation and hydroxymethylation study of alcohol use disorder. Addiction Biology.
27(2), e13114.
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Clark, S. L., Chan, R., Zhao, M., Xie, L. Y., Copeland, W. E., Aberg, K. A., & van den Oord, E.
(2021).
Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences. Journal of the American Academy of Child and Adolescent Psychiatry.
60(12), 1524-1532.
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Verhulst, B., Clark, S. L., Chen, J., Maes, H. H., Chen, X., & Neale, M. C.
(2021).
Clarifying the Genetic Influences on Nicotine Dependence and Quantity of Use in Cigarette Smokers. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
51(4), 375-384.
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Pritikin, J. N., Neale, M. C., Prom-Wormley, E. C., Clark, S. L., & Verhulst, B.
(2021).
GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
51(3), 343-357.
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Zhang, X., Winke, P., & Clark, S.
(2020).
Background Characteristics and Oral Proficiency Development Over Time in Lower-Division College Foreign Language Programs. Language Learning: a journal of research in language studies.
70(3), 807-847.
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Clark, S. L., Hattab, M. W., Chan, R. F., Shabalin, A. A., Han, L., Zhao, M., ... van den Oord, E.
(2020).
A methylation study of long-term depression risk. Molecular Psychiatry.
25(6), 1334-1343.
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Aberg, K. A., Dean, B., Shabalin, A. A., Chan, R. F., Han, L., Zhao, M., ... van den Oord, E.
(2020).
Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. Molecular Psychiatry.
25(6), 1344-1354.
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Kim, M., Clark, S. L., Donnellan, M. B., & Burt, S. A.
(2020).
A multi-method investigation of the personality correlates of digital aggression. Journal of Research in Personality.
85, 103923-103923.
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Verhulst, B., Clark, S., Pritikin, J., Neale, M., & Hettema, J.
(2019).
USING STRUCTURAL EQUATION MODELING (SEM) METHODS TO EXAMINE GENOME-WIDE ASSOCIATIONS WITH A LATENT NEUROTICISM FACTOR AND ITEM-SPECIFIC RESIDUALS. European Neuropsychopharmacology.
29, S126-S126.
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Clark, S., Hattab, M., Shabalin, A., Han, L., Chan, R., Zhao, M., ... van den Oord, E.
(2019).
24 PREDICTING THE FUTURE DISEASE STATUS OF DEPRESSED PATIENTS FROM DNA METHYLATION PATTERNS IN BLOOD. European Neuropsychopharmacology.
29, s793-s794.
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Aberg, K., Dean, B., Shabalin, A., Zhao, M., Chan, R., Hattab, M., ... van den Oord, E.
(2019).
47 METHYLOME-WIDE ASSOCIATION STUDIES FOR MAJOR DEPRESSIVE DISORDER IN BLOOD OVERLAP WITH METHYLATION RESULTS FROM BRAIN AND LARGE-SCALE GWAS. European Neuropsychopharmacology.
29, s807-s808.
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Clark, S., Johnson, A., Chan, R., Xie, L., Zhao, M., Aberg, K., & van den Oord, E.
(2019).
F67A COMPREHENSIVE BRAIN METHYLATION AND HYDROXYMETHYLATION STUDY IN ALCOHOL DEPENDENT PATIENTS. European Neuropsychopharmacology.
29, s1146-S1146.
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Han, L., Aghajani, M., Clark, S., Chan, R., Hattab, M., Shabalin, A., ... Penninx, B.
(2019).
S.14.08 Epigenetic aging in major depressive disorder. European Neuropsychopharmacology.
29, s22-S22.
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Clark, S. L., Costin, B. N., Chan, R. F., Johnson, A. W., Xie, L., Jurmain, J. L., ... van den Oord, E.
(2018).
A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies. Alcoholism: Clinical and Experimental Research.
42(12), 2360-2368.
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Hattab, M. W., Clark, S. L., & van den Oord, E.
(2018).
Overestimation of the classification accuracy of a biomarker for assessing heavy alcohol use. Molecular Psychiatry.
23(11), 2114-2115.
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Aberg, K. A., Shabalin, A. A., Chan, R. F., Zhao, M., Kumar, G., van Grootheest, G., ... van den Oord, E.
(2018).
Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder. Translational Psychiatry.
8(1), 162.
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Han, L., Aghajani, M., Clark, S. L., Chan, R. F., Hattab, M. W., Shabalin, A. A., ... Penninx, B.
(2018).
Epigenetic Aging in Major Depressive Disorder. American Journal of Psychiatry.
175(8), 774-782.
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Shabalin, A. A., Hattab, M. W., Clark, S. L., Chan, R. F., Kumar, G., Aberg, K. A., & van den Oord, E.
(2018).
RaMWAS: fast methylome-wide association study pipeline for enrichment platforms. Bioinformatics.
34(13), 2283-2285.
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Han, L., Verhoeven, J., Aghajani, M., Clark, S., Hattab, M., Shabalin, A., ... Penninx, B.
(2018).
41. Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA). Biological Psychiatry.
83(9), s17-S17.
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Han, L., Aghajani, M., Clark, S., Hattab, M., Shabalin, A., Zhao, M., ... Penninx, B.
(2018).
P.4.001 Accelerated biological aging in major depressive disorder: capturing aging patterns in DNA methylation with machine learning methods. European Neuropsychopharmacology.
28, s87-S86.
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Cho, S. B., Aliev, F., Clark, S. L., Adkins, A. E., Edenberg, H. J., Bucholz, K. K., Porjesz, B., & Dick, D. M.
(2017).
Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders. Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man.
47(4), 405-415.
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Chan, R. F., Shabalin, A. A., Xie, L. Y., Adkins, D. E., Zhao, M., Turecki, G., ... van den Oord, E.
(2017).
Enrichment methods provide a feasible approach to comprehensive and adequately powered investigations of the brain methylome. Nucleic Acids Research (NAR).
45(11), e97-e97.
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Clark, S. L., McClay, J. L., Adkins, D. E., Kumar, G., Aberg, K. A., Nerella, S., ... van den Oord, E. J.
(2017).
Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence. Alcoholism: Clinical and Experimental Research.
41(4), 711-718.
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Hattab, M. W., Shabalin, A. A., Clark, S. L., Zhao, M., Kumar, G., Chan, R. F., ... van den Oord, E.
(2017).
Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies. 18(1), 24.
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van den Oord, E., Clark, S. L., Xie, L. Y., Shabalin, A. A., Dozmorov, M. G., Kumar, G., ... Aberg, K. A.
(2016).
A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue. Schizophrenia Bulletin.
42(4), 1018-1026.
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Cooke, M. E., Nasim, A., Cho, S. B., Kendler, K. S., Clark, S. L., & Dick, D. M.
(2016).
Predicting Tobacco Use across the First Year of College. American Journal of Health Behavior.
40(4), 484-495.
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Clark, S. L., McClay, J. L., Adkins, D. E., Aberg, K. A., Kumar, G., Nerella, S., ... van den Oord, E. J.
(2016).
Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. Nicotine and Tobacco Research.
18(5), 626-631.
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Neale, M. C., Clark, S. L., Dolan, C. V., & Hunter, M. D.
(2016).
Regime Switching Modeling of Substance Use: Time-Varying and Second-Order Markov Models and Individual Probability Plots. Structural Equation Modeling: A Multidisciplinary Journal.
23(2), 221-233.
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Clark, S. L., Gillespie, N. A., Adkins, D. E., Kendler, K. S., & Neale, M. C.
(2016).
Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse. Addictive Behaviors.
53, 132-140.
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McClay, J. L., Shabalin, A. A., Dozmorov, M. G., Adkins, D. E., Kumar, G., Nerella, S., ... van den Oord, E.
(2015).
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction. 16(1), 291.
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Clark, S. L., Aberg, K. A., Nerella, S., Kumar, G., McClay, J. L., Chen, W., ... van den Oord, E.
(2015).
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use. Alcoholism: Clinical and Experimental Research.
39(8), 1396-1405.
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Adkins, D. E., Clark, S. L., Copeland, W. E., Kennedy, M., Conway, K., Angold, A., ... Costello, E. J.
(2015).
Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood. Twin Research and Human Genetics.
18(4), 335-347.
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Brown, R. C., Clark, S. L., Dahne, J., Stratton, K. J., MacPherson, L., Lejuez, C. W., & Amstadter, A. B.
(2015).
Testing the temporal relationship between maternal and adolescent depressive and anxiety symptoms in a community sample. 44(4), 566-579.
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Aberg, K. A., Xie, L., Chan, R. F., Zhao, M., Pandey, A. K., Kumar, G., Clark, S. L., & van den Oord, E.
(2015).
Evaluation of Methyl-Binding Domain Based Enrichment Approaches Revisited. 10(7), e0132205-e0132205.
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Cho, S. B., Llaneza, D. C., Adkins, A. E., Cooke, M., Kendler, K. S., Clark, S. L., & Dick, D. M.
(2015).
Patterns of Substance Use Across the First Year of College and Associated Risk Factors. 6, 152.
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Kumar, G., Clark, S. L., McClay, J. L., Shabalin, A. A., Adkins, D. E., Xie, L., ... van den Oord, E.
(2015).
Refinement of schizophrenia GWAS loci using methylome-wide association data. Human Genetics.
134(1), 77-87.
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Stratton, K. J., Clark, S. L., Hawn, S. E., Amstadter, A. B., Cifu, D. X., & Walker, W. C.
(2014).
Longitudinal interactions of pain and posttraumatic stress disorder symptoms in U.S. Military service members following blast exposure. Pain Forum.
15(10), 1023-1032.
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Kubarych, T. S., Kendler, K. S., Aggen, S. H., Estabrook, R., Edwards, A. C., Clark, S. L., ... Gillespie, N. A.
(2014).
Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study. Twin Research and Human Genetics.
17(2), 89-98.
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McClay, J. L., Aberg, K. A., Clark, S. L., Nerella, S., Kumar, G., Xie, L. Y., ... Van Den Oord, E.
(2014).
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. Human Molecular Genetics.
23(5), 1175-1185.
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Aberg, K. A., McClay, J. L., Nerella, S., Clark, S., Kumar, G., Chen, W., ... van den Oord, E.
(2014).
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry.
71(3), 255-264.
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Guille, C., Clark, S., Amstadter, A. B., & Sen, S.
(2014).
Trajectories of depressive symptoms in response to prolonged stress in medical interns. ACTA PSYCHIATRICA SCANDINAVICA.
129(2), 109-115.
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Wolf, E. J., Harrington, K. M., Clark, S. L., & Miller, M. W.
(2013).
Sample Size Requirements for Structural Equation Models: An Evaluation of Power, Bias, and Solution Propriety. Educational and Psychological Measurement.
76(6), 913-934.
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Adkins, D. E., McClay, J. L., Vunck, S. A., Batman, A. M., Vann, R. E., Clark, S. L., ... Beardsley, P. M.
(2013).
Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization. Genes, Brain and Behavior.
12(8), 780-791.
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Clark, S. L., Muthn, B., Kaprio, J., D'Onofrio, B. M., Viken, R., & Rose, R. J.
(2013).
Models and Strategies for Factor Mixture Analysis: An Example Concerning the Structure Underlying Psychological Disorders. Structural Equation Modeling: A Multidisciplinary Journal.
20(4), 681-703.
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Costello, E. J., Eaves, L., Sullivan, P., Kennedy, M., Conway, K., Adkins, D. E., ... van den Oord, E.
(2013).
Genes, environments, and developmental research: methods for a multi-site study of early substance abuse. Twin Research and Human Genetics.
16(2), 505-515.
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McClay, J. L., Adkins, D. E., Vunck, S. A., Batman, A. M., Vann, R. E., Clark, S. L., Beardsley, P. M., & van den Oord, E.
(2013).
Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure. Metabolomics.
9(2), 392-402.
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Clark, S. L., Souza, R. P., Adkins, D. E., Aberg, K., Bukszr, J., McClay, J. L., Sullivan, P. F., & van den Oord, E.
(2013).
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Pharmacogenetics and Genomics.
23(2), 69-77.
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Adkins, D. E., Souza, R. P., Aberg, K., Clark, S. L., McClay, J. L., Sullivan, P. F., & van den Oord, E.
(2013).
Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR*D. 8(2), e55239-e55239.
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Aberg, K. A., McClay, J. L., Nerella, S., Xie, L. Y., Clark, S. L., Hudson, A. D., ... van den Oord, E.
(2012).
MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples. Epigenomics.
4(6), 605-621.
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Adkins, D. E., Clark, S. L., berg, K., Hettema, J. M., Bukszr, J., McClay, J. L., Souza, R. P., & van den Oord, E.
(2012).
Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. Translational Psychiatry.
2(7), e129-e129.
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Clark, S. L., Adkins, D. E., Aberg, K., Hettema, J. M., McClay, J. L., Souza, R. P., & van den Oord, E.
(2012).
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. Psychological Medicine.
42(6), 1151-1162.
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Wood, J. J., Lynne-Landsman, S. D., Langer, D. A., Wood, P. A., Clark, S. L., Eddy, J. M., & Ialongo, N.
(2012).
School attendance problems and youth psychopathology: structural cross-lagged regression models in three longitudinal data sets. 83(1), 351-366.
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Clark, S. L., Adkins, D. E., & van den Oord, E.
(2011).
Analysis of efficacy and side effects in CATIE demonstrates drug response subgroups and potential for personalized medicine. Schizophrenia Research.
132(2-3), 114-120.
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Mistry, R. S., Benner, A. D., Biesanz, J. C., Clark, S. L., & Howes, C.
(2010).
Family and social risk, and parental investments during the early childhood years as predictors of low-income children's school readiness outcomes. Early Childhood Research Quarterly.
25(4), 432-449.
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Boomsma, D. I., Cacioppo, J. T., Muthn, B., Asparouhov, T., & Clark, S.
(2007).
Longitudinal genetic analysis for loneliness in Dutch twins. Twin Research and Human Genetics.
10(2), 267-273.
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Ingram, S. J., Vazquez, A. Y., Klump, K. L., Hyde, L. W., Burt, S. A., & Clark, S. L.
(2024).
Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging. JOURNAL OF AFFECTIVE DISORDERS.
352, 250-258.
-
conference paper
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van den Oord, E., Xie, L. Y., Zhao, M., Aberg, K. A., & Clark, S. L.
(2023).
A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens. Addiction Biology.
e13250-72A.
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Clark, S. L., Zhao, M., Xie, L. Y., Penninx, B., Copeland, W. E., Aberg, K. A., & van den Oord, E.
(2023).
DNA methylation biomarkers of alcohol use disorder. 116-117.
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Clark, S. L., Chan, R. F., Zhao, M., Xie, L. Y., Penninx, B., Aberg, K. A., & van den Oord, E.
(2021).
DUAL METHYLATION AND HYDROXYMETHYLATION STUDY IN BLOOD AND BRAIN IDENTIFIES BAIAP2 AS A MEDIATOR OF GENE EXPRESSION ASSOCIATED WITH ALCOHOL USE DISORDER. Alcoholism: Clinical and Experimental Research.
98A-98A.
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van den Oord, E., Xie, L. Y., Zhao, M., Aberg, K. A., & Clark, S. L.
(2023).
A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens. Addiction Biology.
e13250-72A.
-
institutional repository document
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Andrade-Brito, D. E., Nez-Ros, D. L., Martnez-Magaa, J. J., Nagamatsu, S. T., Rompala, G., Zillich, L., ... Montalvo-Ortiz, J. L.
(2023).
Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder
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van den Oord, E., Xie, L. Y., Zhao, M., Aberg, K. A., & Clark, S. L.
(2022).
A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens
-
Clark, S. L., Chan, R. F., Zhao, M., Xie, L. Y., Copeland, W. E., Penninx, B., Aberg, K. A., & van den Oord, E.
(2020).
Dual methylation and hydroxymethylation study of alcohol use disorder
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Andrade-Brito, D. E., Nez-Ros, D. L., Martnez-Magaa, J. J., Nagamatsu, S. T., Rompala, G., Zillich, L., ... Montalvo-Ortiz, J. L.
(2023).
Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder
Research
principal investigator on
co-principal investigator on
Teaching
teaching activities
- GENE691 Research Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Background
education and training
- University of California Los Angeles - (Los Angeles, California, United States)
- M.A. in Advanced Quantitative Methods, University of California Los Angeles - (Los Angeles, California, United States) 2004
- B.A. in Statistics, University of California, Berkeley - (Berkeley, California, United States) 2003
Contact
first name
- Shaunna
has last name
- Clark
Other
- slclark@tamu.edu