Dr. Clark's research seeks to understand how biological and environmental factors shape substance use and addiction. Specifically, the lab focuses on the role of genetics and epigenetics in the etiology of substance use and addiction and identifying (epi)genetic biomarkers. This line of research will eventually lead to the improvement of diagnosis, prognosis and treatment of substance addiction and its related health effects. We approach these research questions using a translational framework that incorporates both human and animal studies, big data, and advanced statistical modeling techniques.